CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 34 enrolled
Drug / intervention
Intensive intermittent theta-burst stimulation (iTBS)device
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05228457
NCT05228457N/ACompleted
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Intensive TMS for Rapid Relief of Bipolar Depression Symptoms

University of Pennsylvania·interventional·Posted Feb 8, 2022·Updated Mar 12, 2025

In Brief

A clinical study evaluating Intensive intermittent theta-burst stimulation (iTBS) for Bipolar Depression and Treatment Resistant Depression. Completed, enrolled 34 participants across 1 site.

Detailed Summary

The research study is being conducted to test whether using high dose spaced theta-burst rTMS (a form of transcranial magnetic stimulation) produces a significant reduction in depressive symptoms compared with sham. This project will recruit patients aged 18-70 with symptoms of bipolar depression who have failed (or not shown signs of improvement) after at least two prior treatments.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsBipolar Depression, Treatment Resistant Depression
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
20222023202420252026
First PostedFeb 8, 2022
Enrollment StartMar 1, 2022
Primary CompletionFeb 19, 2024
TodayJul 2, 2026
Enrollment to primary: 2.0 yearsPosted 4.4 years ago

Interventions

Intensive intermittent theta-burst stimulation (iTBS)device

Intensive iTBS is intermittent theta-burst stimulation (iTBS), a patterned form of repetitive transcranial magnetic stimulation (rTMS) over a specific brain region.