CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 125 enrolled
Drug / intervention
Defined CBD +1 moredrug
Likely dose
Defined CBD 300 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05233761
NCT05233761Phase 2Completed

Le Rêve 3.0: A Double-Blind, Placebo-Controlled, Randomized, Crossover Investigational Study to Determine if Defined CBD, a Capsule With a Custom Formulation of Cannabidiol (CBD) and Terpenes, Influences Sleep Physiology

Defined Research·interventional·Posted Feb 10, 2022·Updated Sep 11, 2025

In Brief

A Phase 2 clinical trial evaluating Defined CBD and Placebo for Insomnia. Completed, enrolled 125 participants across 1 site.

Detailed Summary

Insomnia is a disorder in which people have inadequate or poor-quality sleep due to a number of factors, such as difficulty falling asleep, waking up frequently during the night with difficulty returning to sleep, waking up too early in the morning, or having unrefreshing sleep. Defined CBD is a capsule composed of highly purified (\>99.9%) hemp-derived cannabidiol (CBD) and terpenes produced as a potential sleep aid for people with insomnia. This product contains no detectable Delta-9-tetrahydrocannabinol (Delta-9-THC). This trial is specifically designed to evaluate the efficacy of Defined CBD on sleep physiology in people with insomnia.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsInsomnia
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
20222023202420252026
First PostedFeb 10, 2022
Enrollment StartFeb 18, 2022
Primary CompletionJul 2, 2022
TodayJul 2, 2026
Enrollment to primary: 4 monthsPosted 4.4 years ago

Interventions

Defined CBDdrug

300 mg CBD and 8 mg Terpenes administered as two small capsules.

Placebodrug

Capsules that smell and look exactly like Defined CBD but contain no CBD or terpenes.