CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 469 enrolled
Drug / intervention
RTX-GRT7039 +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05248386
NCT05248386Phase 3Completed

A Randomized, Double-blind, Placebo-controlled, Phase III Trial to Evaluate the Efficacy and Safety of Intra-articular Injections of RTX-GRT7039 in Adult Subjects With Pain Associated With Osteoarthritis of the Knee

Grünenthal GmbH·interventional·Posted Feb 21, 2022·Updated Mar 18, 2026

In Brief

A Phase 3 clinical trial evaluating RTX-GRT7039 and Placebo for Osteoarthritis. Completed, enrolled 469 participants across 103 sites in 9 countries.

Detailed Summary

A double-blind, randomized, placebo-controlled, parallel-group, multi-site, clinical trial to confirm the efficacy and safety of repeated injections of RTX-GRT7039 versus placebo in patients who have pain associated with osteoarthritis of the knee despite standard of care.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsOsteoarthritis
CountriesCanada, Czechia, France, Germany, Italy, Japan, Mexico, Netherlands, Poland
Collaborators--

Timeline

Phase 3CompletedFinished
2023202420252026
First PostedFeb 21, 2022
Enrollment StartAug 26, 2022
Primary CompletionNov 18, 2024
TodayJul 2, 2026
Enrollment to primary: 2.2 yearsPosted 4.4 years ago

Interventions

RTX-GRT7039drug

RTX-GRT7039 intra-articular injection.

Placebodrug

Placebo matching RTX-GRT7039 intra-articular injection.