At a glance
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Frequency of Endometrial Cancer Precursors Associated with Lynch Syndrome
In Brief
An observational study evaluating Immunohistochemical staining for Lynch Syndrome and 4 related conditions. Completed, enrolled 91 participants across 1 site.
Detailed Summary
Given that there is a significant prevalence of Lynch syndrome among patients with endometrial cancer (about 5% of patients with endometrial cancer), and given there is a known risk of endometrial cancer among patients with endometrial hyperplasia (40% risk of pre-existing occult cancer with endometrial intraepithelial neoplasia), it is hypothesized that a diagnosis of endometrial hyperplasia may herald on-going risk of harboring a Lynch Syndrome gene mutation. The purpose of this study is to examine endometrial hyperplasia specimens and compare the frequency of Lynch Syndrome gene mutations between endometrial hyperplasia and endometrial cancer subjects. This will provide a rationale and opportunity for earlier screening, and reduce colon cancer morbidity and mortality secondary to the Lynch syndrome gene.
Study Details
Timeline
Interventions
Immunohistochemistry will be performed on the endometrial tissue specimens