CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 60 enrolled
Drug / intervention
ClōSYS® Sensitive Fluoride Toothpaste +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05258721
NCT05258721Phase 2Completed
CompareCT.gov

Efficacy of ClōSYS® Sensitive Fluoride Toothpaste and ClōSYS® Sensitive Rinse Regimen on Plaque, Gingival Inflammation and Bleeding Upon Probing

Rowpar Pharmaceuticals, Inc.·interventional·Posted Feb 28, 2022·Updated Aug 15, 2025

In Brief

A Phase 2 clinical trial evaluating ClōSYS® Sensitive Fluoride Toothpaste and ClōSYS® Sensitive Rinse for Gingivitis and Periodontitis. Completed, enrolled 60 participants across 1 site.

Detailed Summary

90-day, self-controlled, longitudinal, non-blinded clinical trial which will measure changes in clinical parameters in participants with gingivitis and Stage I or II periodontitis who apply ClōSYS® Sensitive Fluoride Toothpaste and ClōSYS® Sensitive Rinse.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsGingivitis, Periodontitis
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
20222023202420252026
First PostedFeb 28, 2022
Enrollment StartJul 6, 2021
Primary CompletionOct 31, 2022
TodayJul 2, 2026
Enrollment to primary: 1.3 yearsPosted 4.3 years ago

Interventions

ClōSYS® Sensitive Fluoride Toothpastedrug

ClōSYS® Sensitive Fluoride Toothpaste is an over-the-counter drug product containing 0.12% stabilized chlorine dioxide (sodium chlorite in an aqueous solution) and 0.13% w/v fluoride ion.

ClōSYS® Sensitive Rinseother

ClōSYS® Sensitive Rinse is a cosmetic product containing 0.1% stabilized chlorine dioxide.