At a glance
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Modulation of the Gut-brain Axis by Cranberries: Impact on University Students' Mental Wellbeing
In Brief
A clinical study evaluating Cranberry juice and Placebo for Healthy. Completed, enrolled 64 participants across 1 site.
Detailed Summary
In this work, the investigators will assess whether cranberry (poly)phenols improve mood disorders including stress, anxiety and depression via the gut-brain axis in university students. The investigators will evaluate whether the effects observed are related to an improvement in gut microbiome diversity and function, and whether the mechanism of action may be mediated by a decrease in inflammatory markers, modulation of neurotransmitters or via an alteration of BDNF levels. The investigators will also quantify the most comprehensive panel of cranberry (poly)phenol metabolites. A double-blind, randomized placebo controlled 2-arm parallel study will be conducted in the Metabolic Research Unit (MRU, Department of Nutritional Sciences at KCL).
Study Details
Timeline
Interventions
composition: Water, cranberry juice concentrate
composition: Water, dextrose, citric acid, malic acid, fumaric acid, colorants, xanthan gum, natural flavor, emulsion