CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 112 enrolled
Drug / intervention
Office-based Vergence and Accommodative Therapybehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05262361
NCT05262361N/ACompleted

Functional Mechanism of Neural Control in Persistent Post-Concussion Symptoms Convergence Insufficiency

New Jersey Institute of Technology·interventional·Posted Mar 2, 2022·Updated Jan 22, 2026

In Brief

A clinical study evaluating Office-based Vergence and Accommodative Therapy for Persistent Post-concussive Symptoms and 4 related conditions. Completed, enrolled 112 participants across 2 sites.

Detailed Summary

Our successful R01 discovered 1) the neural mechanistic difference between typically occurring convergence insufficiency (TYP-CI) and binocularly normal controls and 2) the underlying mechanism of office-based vergence and accommodative therapy (OBVAT) that is effective in remediating symptoms. Adolescent and young adult concussion is considered a substantial health problem in the United States where our team has shown that about half of patients with persistent post-concussion symptoms have convergence insufficiency (PPCS-CI), causing significant negative impact associated with reading or digital screen-related activities, and is believed to be one factor causing delayed recovery impacting return to school, sports, or work. The results of this randomized clinical trial will impact the lives of adolescents and young adults with PPCS-CI to guide professionals on how to manage and treat those with PPCS-CI by 1) comparing the differences between PPCS-CI and TYP-CI, 2) discovering the neural mechanism of OBVAT for PPCS-CI compared to standard-community concussion care, and 3) determining the effectiveness of 12 one-hour sessions compared to 16 one-hour sessions of OBVAT.

Study Details

Timeline

N/ACompletedFinished
20222023202420252026
First PostedMar 2, 2022
Enrollment StartSep 1, 2021
Primary CompletionJan 19, 2026
TodayJul 2, 2026
Enrollment to primary: 4.4 yearsPosted 4.3 years ago

Interventions

Office-based Vergence and Accommodative Therapybehavioral

Office-based Vergence and Accommodative Therapy has four phases which start with gross vergence and accommodation. Disparity vergence is isolated using instruments such as vectograms and accommodation is isolated using near far charts and accommodative rock. The final phase includes the integration of vergence and accommodation to increase range and visual comfort which performing activities close to the person.