CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 9,586 enrolled
Drug / intervention
Duloxetine, Vortioxetinedrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05267873
NCT05267873N/ACompleted
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Combining Data Sources to Identify Effect Moderation for Personalized Mental Health

Johns Hopkins Bloomberg School of Public Health·observational·Posted Mar 4, 2022·Updated Apr 13, 2026

In Brief

An observational study evaluating Duloxetine, Vortioxetine for Depressive Disorder, Major. Completed, enrolled 9,586 participants across 1 site.

Detailed Summary

This work will extend and apply methods for modeling heterogeneous treatment effects when multiple studies are available, with a particular focus on the complexities in mental health research. The methods will be illustrated in examples estimating the effects of medical treatments for major depressive disorder (duloxetine and vortioxetine) using 4 randomized controlled trials (available in the Vivli trials resource) and non-experimental data from the Duke University Health System electronic health record and the Johns Hopkins Health System electronic health record systems.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsDepressive Disorder, Major
CountriesUnited States
CollaboratorsDuke University, Patient-Centered Outcomes Research Institute, National Institute of Mental Health (NIMH)

Timeline

N/ACompletedFinished
201520162017201820192020202120222023202420252026
First PostedMar 4, 2022
Enrollment StartJan 1, 2015
Primary CompletionDec 31, 2021
Study CompletionDec 1, 2024
TodayJul 2, 2026
Enrollment to primary: 7 yearsPosted 4.3 years ago

Interventions

Duloxetine, Vortioxetinedrug

Medications for major depressive disorder