CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 211 enrolled / 211 target
Drug / intervention
Guselkumab +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05272150
NCT05272150Phase 3CompletedMonitor (4.4/mo)Completion was 13mo ago

CNTO1959PSO3018: A Phase 3b, Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Safety and Efficacy of Guselkumab for the Treatment of Participants With Skin of Color Who Have Moderate-to-Severe Plaque Psoriasis and/or Moderate

Janssen Research & Development, LLC·interventional·Posted Mar 9, 2022·Updated Jun 24, 2026

In Brief

A Phase 3 clinical trial evaluating Guselkumab and Placebo for Plaque Psoriasis and Scalp Psoriasis. Completed, enrolled 211 participants across 94 sites in 2 countries.

Signals

Enrolling slower than its timeline implies

Detailed Summary

The purpose of this study is to evaluate the efficacy of guselkumab treatment versus placebo in skin of color participants with predominant moderate-to-severe body psoriasis or predominant moderate-to-severe scalp psoriasis by assessing improvements in the signs and symptoms of psoriasis.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesCanada, United States
Collaborators--

Timeline

Phase 3CompletedFinished
2023202420252026
First PostedMar 9, 2022
Enrollment StartJul 13, 2022
Primary CompletionMay 30, 2025
TodayJul 2, 2026
Enrollment to primary: 2.9 yearsPosted 4.3 years ago

Arms & Interventions

Cohort A: Moderate-to-severe Plaque Psoriasisexperimental

Participants will receive either guselkumab subcutaneously (SC) or placebo SC. Placebo participants will then crossover to receive guselkumab SC.

Drug: GuselkumabDrug: Placebo
Cohort B: Moderate-to-severe Scalp Psoriasisexperimental

Participants will receive either guselkumab SC or placebo SC. Placebo participants will then crossover to receive guselkumab SC.

Drug: GuselkumabDrug: Placebo

Interventions

Guselkumabdrug

Participants will receive guselkumab as subcutaneous injection.

Placebodrug

Participants will receive placebo as subcutaneous injection.