CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 12 enrolled
Drug / intervention
(R)-3-hydroxybutyl (R)-3-hydroxybutyrate ketone monoester +2 moredietary
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05273411
NCT05273411N/ACompleted

The Effect of Different Ketone Supplements on Blood Beta-hydroxybutyrate (β-OHB) and Blood Glucose in Healthy Individuals

University of British Columbia·interventional·Posted Mar 10, 2022·Updated Aug 1, 2024

In Brief

A clinical study evaluating (R)-3-hydroxybutyl (R)-3-hydroxybutyrate ketone monoester, Beta-hydroxybutyric acid, and 1 other intervention for Ketosis and Blood Glucose. Completed, enrolled 12 participants across 1 site.

Detailed Summary

Ketone bodies are a fuel source and signaling molecule that are produced by your body during prolonged fasting or if you consistently eat at low-carbohydrate diet. Blood ketones can be used as a source of energy during fasting and are used by your brain as an alternative source of fuel to glucose. Previous studies have found that ketones, when consumed in form of a supplement drink, can increase blood ketone levels and lower blood glucose, the amount of sugar in your blood. This is of potential interest for individuals with high blood sugar, such as people living with type 2 diabetes. However, there are different types of ketone supplements that differ in how they are metabolized in the body. Little is known about how these supplements affect blood ketone and blood glucose levels. The main objective of this study is to determine the effect of three different ketone supplements on blood ketones and blood glucose. The results of this pilot study will be used to guide future research for larger and more extensive studies on ketone supplements.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesCanada
Collaborators--

Timeline

N/ACompletedFinished
2023202420252026
First PostedMar 10, 2022
Enrollment StartMar 24, 2022
Primary CompletionMay 18, 2022
TodayJul 2, 2026
Enrollment to primary: 2 monthsPosted 4.3 years ago

Interventions

(R)-3-hydroxybutyl (R)-3-hydroxybutyrate ketone monoesterdietary

Single-dose pharmacokinetic study over 4 hours.

Beta-hydroxybutyric aciddietary

Beta-hydroxybutyric acid

1,3-Butanedioldietary

1,3-Butanediol