At a glance
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The Randomized Trial of Sedative Choice for Intubation
In Brief
A Phase 4 clinical trial evaluating Ketamine and Etomidate for Acute Respiratory Failure. Completed, enrolled 2,367 participants across 6 sites.
Detailed Summary
Among critically ill adults undergoing emergency tracheal intubation, one in five experience hypotension, cardiac arrest, or death. The sedatives used to rapidly induce anesthesia for emergency tracheal intubation have been hypothesized to effect cardiovascular complications and patient outcomes, but the optimal sedative medication for intubation of critically ill adults remains unknown. Ketamine and etomidate are the two most commonly used sedatives during intubation of critically ill adults. Data from a randomized clinical trial are urgently needed to determine the effect of ketamine versus etomidate on cardiovascular complications and clinical outcomes of emergency tracheal intubation.
Study Details
Timeline
Interventions
Intravenous ketamine as the sedative for induction of anesthesia during emergency tracheal intubation
Intravenous etomidate as the sedative for induction of anesthesia during emergency tracheal intubation