At a glance
ClinicalIndex Comparison Record- ✓Age ≥60 years
- ✓Undergoing cardiac surgery with cardiopulmonary bypass: CABG, CABG+valve surgery, or isolated valve surgery
- ✕Preoperative left ventricular ejection fraction (LVEF) <30%
- ✕Emergent surgery
- ✕Cognitive impairment (Montreal Cognitive Assessment score <10)
- ✕Non-English speaking
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies - the PATHFINDER II Study
In Brief
A clinical study evaluating EEG Monitoring, Ropivacaine, and 5 other interventions for Postoperative Delirium and 3 related conditions. Completed, enrolled 70 participants across 1 site.
Detailed Summary
In the PATHFINDER 2 trial, the study investigators will test the intraoperative EEG-guided multimodal general anesthesia (MMGA) management strategy in combination with a postoperative protocolized analgesic approach to: 1. reduce the incidence of perioperative neurocognitive dysfunction in cardiac surgical patients 2. ensure hemodynamic stability and decrease use of vasopressors in the operating rooms 3. reduce pain and opioid consumption postoperatively
Study Details
Timeline
Interventions
Perioperative monitoring, MMGA guided by EEG for intervention group
Intraoperative bilateral PIFB block with 20 mL of 0.2% Ropivicaine on either side of the sternum after anesthetic induction but before surgical incision (total of 40mL) PIFB on postoperative day 1 (provided they are extubated or getting ready to be extubated) to help with mobilization (for intervention group)
Intraoperative infusion
Intraoperative infusion
Intraoperative infusion
Intraoperative intermittent bolus
Intraoperative infusion