At a glance
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Evaluation of the Effect of Non-surgical Periodontal Treatment on Salivary and Gingival Crevicular Fluid Levels of IL-17 and IL-35 in Periodontitis Patients as Smoker and Non-smoker
In Brief
A clinical study evaluating Non-surgical periodontal treatment for Periodontitis and 3 related conditions. Completed, enrolled 55 participants across 2 sites.
Detailed Summary
Periodontal diseases are among the major causes of tooth loss. Smoking may play a role as a contributing factor in the development of periodontitis by reducing the immune response. The role of cytokines in the pathogenesis of periodontal disease is clearly indicated in the literature; it has been shown that microorganisms that cause periodontal disease cause cytokine increase in saliva, gingival tissue and gingival crevicular fluid. Among these cytokines, interleukin (IL) -17 is proinflammatory and IL-35 is antiinflammatory and has been associated with periodontal disease.
Study Details
Timeline
Interventions
Non-surgical periodontal treatment includes periodontal prophylaxis and root planning. No other methods or any of drugs will be used.