CI

At a glance

ClinicalIndex Comparison Record
Phase 1Active· 24 enrolled
Drug / intervention
Tumor Associated Antigen Peptide Vaccine P30-EPS Vaccine +1 morebiological
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05283109
NCT05283109Phase 1Active
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ETAPA I: Evaluation of Tumor Associated P30-Peptide Antigen I; A Pilot Trial of Peptide-based Tumor Associated Antigen Vaccines in Newly Diagnosed, Unmethylated, and Untreated Glioblastoma (GBM)

Mustafa Khasraw, MBChB, MD, FRCP, FRACP·interventional·Posted Mar 16, 2022·Updated Apr 30, 2026

In Brief

A Phase 1 clinical trial evaluating Tumor Associated Antigen Peptide Vaccine P30-EPS Vaccine and Hiltonol for Glioma, Malignant. Active but no longer recruiting, targeting 24 participants across 1 site.

Detailed Summary

This is a phase 1b study of P30-linked EphA2, CMV pp65, and survivin vaccination (collectively called the P30-EPS vaccine) in HLA-A\*0201 positive patients with a newly diagnosed, unmethylated, and untreated World Health Organization (WHO) grade IV malignant glioma.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsGlioma, Malignant
CountriesUnited States
CollaboratorsNational Cancer Institute (NCI)

Timeline

Phase 1Active
202320242025202620272028
First PostedMar 16, 2022
Enrollment StartAug 30, 2023
Primary CompletionApr 11, 2025
Study CompletionFeb 28, 2028
TodayJul 2, 2026
Enrollment to primary: 1.6 yearsPosted 4.3 years ago

Interventions

Tumor Associated Antigen Peptide Vaccine P30-EPS Vaccinebiological

Vaccine that includes 3 peptides (EphA2 linked to P30 peptide, pp65 linked to P30 peptide, and Survivin linked to P30 peptide)

Hiltonoldrug

Hiltonol® is made up of synthetic (manmade) RNA (ribonucleic acid) and is used as an adjuvant to the vaccine, meaning it is used with the vaccine to stimulate or enhance the activation of your immune system.