At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Intravenous Hydration After Surgery Using Boluses of Balanced Salt Solution
In Brief
A Early Phase 1 clinical trial evaluating Urinalysis (UA), Complete Metabolic Panel (CMP), and 2 other interventions for Dehydration in Children and Fluid Therapy. Completed, enrolled 70 participants across 1 site.
Detailed Summary
Traditional protocols for intravenous fluid administration in children who have undergone a major abdominal or thoracic operation are based on a landmark paper published in 1957 by Holliday and Segar. The basic tenets include: (1) Continuous intravenous fluid administration; (2) Total fluid volume based on the "4:2:1" rule; (3) Use of hypotonic electrolyte solutions, most commonly 0.45% sodium chloride (NaCl) + 20 milliequivalents per liter (mEq/L) potassium chloride (KCl); and (4) Inclusion of 5% dextrose to increase the osmolarity of the infusate and to help prevent ketosis and acidemia.
Study Details
Timeline
Interventions
Urinalysis will be performed twice daily starting on Postoperative Day 0.
A CMP will be performed on Postoperative Day 2 and Postoperative Day 4.
A d-Stick will be performed twice daily except on Postoperative Day 2 and Postoperative Day 4 as the CMP includes serum glucose levels.
A medical chart review will be performed for all subjects enrolled.