At a glance
ClinicalIndex Comparison Record- ✓Nulliparous (no prior vaginal deliveries)
- ✓Age > 18 years
- ✓Gestational age ≥37 weeks 0 days
- ✓Singleton pregnancy
- ✕Prior uterine surgery (cesarean, myomectomy, etc.)
- ✕Non-reassuring fetal status as indication for induction
- ✕Fetal demise
- ✕Major fetal congenital malformation or known chromosomal abnormality
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
The HILIO Trial: High vs. Low Oxytocin Dosing for Induction of Labor in Pregnant Patients With Obesity- PILOT STUDY
In Brief
A Phase 4 clinical trial evaluating High-dose oxytocin and Low-dose oxytocin for Pregnant Patients With Obesity. Completed, enrolled 20 participants across 1 site.
Detailed Summary
Pregnant patients with obesity are more likely to undergo induction of labor and have a higher risk of failed induction compared to patients with normal weight. The association between maternal obesity and labor dysfunction leading to cesarean delivery is poorly understood. Oxytocin is the mostly common medication used in induction of labor, yet optimal dosing of this medication is unknown. Studies have suggested that patients with obesity may be less responsive to oxytocin. This trial will compare a high and low dose oxytocin dosing regimen for the induction of labor in women with obesity.
Study Details
Timeline
Interventions
Starting dose 6 mU/min and increased by 6 mU/min every 30 minutes until adequate contractions achieved, at the discretion of the obstetric providers.
Starting dose 2 mU/min and increased by 2 mU/min every 30 minutes until adequate contractions achieved, at the discretion of the obstetric providers.