At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Fasting-Associated Immune-metabolic Remission of Diabetes Type 2
In Brief
A clinical study evaluating weight loss by very low energy diet intake which may differ in protein or carbohydrate content for Type 2 Diabetes Mellitus and Obesity. Completed, enrolled 52 participants across 1 site.
Detailed Summary
People with a body mass index above 28 kg/m² and an onset of type 2 diabetes within the last 4 years had a remission (HbA1c \<6.5% without medication) of diabetes in over 80% upon weight loss of 15 kg. Longer duration of diabetes reduced the chance of remission. The investigators will test whether there is a difference in remission upon weight loss of 15 kg using formula low calorie diets between subjects with a diabetes duration of \<4 years vs. \>8 years and oral treatment as primary end points. The immune metabolic programming of circulating monocytes will be investigated in detail regarding trained innate immunity and the endocrine responses will be determined using meal challenge tests.
Study Details
Timeline
Interventions
The anthropometric, endocrine and metabolic status is tested before, after 7 days and after 15 kg weight loss