CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 41 enrolled
Drug / intervention
Dexmedetomidine +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05321121
NCT05321121Phase 4Completed

Dexmedotomidine for Acute Pain Control in Patients With Multiple Rib Fractures

University of California, Irvine·interventional·Posted Apr 11, 2022·Updated Mar 25, 2026

In Brief

A Phase 4 clinical trial evaluating Dexmedetomidine and Placebo for Rib Fractures and Pain, Acute. Completed, enrolled 41 participants across 1 site.

Detailed Summary

Blunt chest trauma is the second most common form of unintentional trauma in the US and is associated with significant morbidity and mortality. Thoracic injuries are the third most common cause of death in trauma patients. Rib fractures have an increased associated risk of pneumonia, prolonged hospitalization, and cost. The associated severe pain leads to poor pulmonary mechanics, which contributes to additional complications. Treatment for rib fractures is focused on optimizing analgesia and intense pulmonary hygiene. Most common strategies utilize early mobilization, incentive spirometry (IS), and multimodal pain regimens. A variety of techniques for analgesia after blunt chest trauma exist. Epidural analgesia is one of the best-studied methods and can often provide significant pain relief. However, this method is invasive, has associated complications, and often can be contraindicated due to coagulopathy or other injuries. Most often a form of multimodal pain strategy is utilized which incorporates acetaminophen, Nonsteroidal anti-inflammatory drugs (NSAIDs), trans-dermal lidocaine, and muscle relaxants. Opioids remain an important adjunct to control severe pain, however, narcotics have their own associated complications. The aim of our study is to use an infusion of dexmedetomidine (Precedex) to aid in pain management in patients presenting with 3 or more rib fractures. The investigators hypothesize that dexmedetomidine will decrease patient pain and opioid use.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

Phase 4CompletedFinished
20222023202420252026
First PostedApr 11, 2022
Enrollment StartNov 12, 2021
Primary CompletionOct 21, 2023
TodayJul 2, 2026
Enrollment to primary: 1.9 yearsPosted 4.2 years ago

Interventions

Dexmedetomidinedrug

Dexmedotomidine for Acute Pain Control in Patients with Multiple Rib Fractures

Placeboother

The control arm will receive an infusion of normal saline