At a glance
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Contrast-Enhanced Ultrasound for Diagnosis and Therapy of Cholangiocarcinoma
In Brief
A Phase 2 clinical trial evaluating Perflutren Protein-Type A Microspheres and Contrast-Enhanced Ultrasound for Intrahepatic Cholangiocarcinoma. Completed, enrolled 16 participants across 1 site.
Detailed Summary
This phase II trial tests whether contrast-enhanced ultrasound can predict the response of bile duct cancer to targeted radiotherapy (radioembolization treatment). Contrast-enhanced ultrasound uses gas microbubbles that may provide enhancement on ultrasound. It is also possible to pop these microbubbles using ultrasound imaging. Tumors that experience popping of these microbubbles may be easier to kill with radiotherapies. Therefore, this trial may also help doctors see if ultrasound-triggered microbubble popping can improve bile duct cancer response to radiotherapy. Another purpose of this trial is to test if the pressure inside the tumor estimated through ultrasound can be used to predict the tumor response to radiotherapy.
Study Details
Timeline
Interventions
Given IV
Undergo CEUS