CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 14 enrolled
Drug / intervention
Impact Load Exercises +1 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05341700
NCT05341700N/ACompleted
CompareCT.gov

The Effect of Impact Loading on Bone Biomarkers in Energy-Restricted Female Runners

Virginia Polytechnic Institute and State University·interventional·Posted Apr 22, 2022·Updated Aug 19, 2025

In Brief

A clinical study evaluating Impact Load Exercises and No Impact Load Exercises for Relative Energy Deficiency in Sport. Completed, enrolled 14 participants across 1 site.

Detailed Summary

This study is a randomized, cross-over intervention study that will evaluate the effect of brief, high-impact loading exercises on biomarkers of bone metabolism in energy-restricted female runners. Volunteers will complete two 5-day experimental conditions in a randomized order separated by one menstrual cycle (approximately 3 weeks). Experimental conditions will include a dietary intervention of energy intake equal to 30 kcal/kg of fat-free mass/d using controlled diets and an exercise intervention of daily treadmill running with or without an additional 50 impact loading exercises.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsRelative Energy Deficiency in Sport
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
2023202420252026
First PostedApr 22, 2022
Enrollment StartAug 24, 2022
Primary CompletionJan 23, 2024
Study CompletionApr 12, 2024
TodayJul 2, 2026
Enrollment to primary: 1.4 yearsPosted 4.2 years ago

Interventions

Impact Load Exercisesbehavioral

Participants will complete 50-65 min running protocol on treadmill and 5 sets of 10 jumping exercises for 5 consecutive days. Participants will also be provided all meals and snacks to induce a energy-restricted state for the 5-day period.

No Impact Load Exercisesbehavioral

Participants will complete only a 50-65 min running protocol on treadmill for 5 consecutive days. Participants will also be provided all meals and snacks to induce a energy-restricted state for the 5-day period.