At a glance
ClinicalIndex Comparison Record- ✓Age 60-85 years
- ✓No dementia diagnosis, and meets CCNA criteria for cognitively unimpaired (CU), CU with subjective cognitive impairment (CU+SCI), or mild cognitive impairment (MCI)
- ✓At least one dementia risk factor: first-degree family history of dementia, OR midlife hypertension/hypercholesterolemia/obesity (BMI>30)/physical inactivity
- ✓Sufficient English or French proficiency for remote assessment and online participation
- ✕Clinical diagnosis of dementia
- ✕Clinical Dementia Rating (CDR) score >1
- ✕Montreal Cognitive Assessment (MoCA) total score <13
- ✕Insufficient English or French proficiency for remote assessment and online participation
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
The Canadian Therapeutic Platform Trial for Multidomain Interventions to Prevent Dementia: Brain Health Support Program Intervention
In Brief
A clinical study evaluating Brain Health PRO for Dementia Prevention and 3 related conditions. Completed, enrolled 354 participants across 7 sites.
Detailed Summary
The Canadian Therapeutic Platform Trial for Multidomain Interventions to Prevent Dementia (CAN-THUMBS UP, or CTU) is a comprehensive and innovative program aimed to develop, implement and evaluate an interactive and compelling online educational Brain Health Support Program (BHSP) intervention, called Brain Health PRO (BHPro), with potential to positively influence dementia literacy, lifestyle risk factors, and scale-up to reach the broader Canadian public; enroll and retain a community-dwelling Platform Trial Cohort (PTC) of individuals at risk of dementia; and support an open platform trial to test a variety of multidomain interventions that might further benefit individuals at risk of dementia.
Study Details
Timeline
Interventions
BHPro is a 45-week, multidomain web-based formal educational program which has been designed to increase dementia literacy, convey best available evidence for lifestyle changes that can mitigate dementia risk, and foster engagement toward one's own brain health.