At a glance
ClinicalIndex Comparison Record- ✓Age 20–45 years
- ✓Normal weight (BMI 18.5–24.9 kg/m²)
- ✓Able to speak and read English
- ✓Non-smoker
- ✕History of chronic cardiometabolic disease (diabetes, hypertension, hyperlipidemia, heart disease)
- ✕Excessive alcohol consumption
- ✕History of weight loss surgery or liposuction
- ✕Use of weight loss medications in previous 6 months
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Mechanism of Monocyte Priming in Humans - a Feeding Trial
In Brief
A clinical study evaluating Experimental diet for Heart Diseases. Completed, enrolled 8 participants across 1 site.
Detailed Summary
To determine the mechanism of monocyte priming in humans, the study team will conduct a complete feeding trial in normal weight and metabolically healthy human subjects (20-45 years of age) using a western diet (WD), characterized as being high-saturated fat, high-fructose, and high-calorie for 8 weeks.
Study Details
Timeline
Interventions
Participants that successfully complete the run-in phase will participate in the experimental diet for 8 weeks of feeding. The Participants' adherence will be monitored using direct observation, written daily food diaries, and food waste inventory (i.e., participants are trained to estimate portion of uneaten foods). Participants will be asked to eat one meal onsite 2-3 weekdays (e.g., Monday, Wednesday, and Friday), at which time they will receive meals and snacks for the remainder of that day and enough until the next scheduled visit.