CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 205 enrolled
Drug / intervention
Izokibep +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05355805
NCT05355805Phase 2Completed

A Phase 2b Study to Evaluate the Efficacy and Safety of Izokibep in Subjects With Moderate to Severe Hidradenitis Suppurativa

ACELYRIN Inc.·interventional·Posted May 2, 2022·Updated Jun 3, 2025

In Brief

A Phase 2 clinical trial evaluating Izokibep and Placebo to izokibep for Hidradenitis Suppurativa. Completed, enrolled 205 participants across 44 sites in 6 countries.

Detailed Summary

Izokibep is a potent and selective inhibitor of interleukin 17A (IL-17A) that is being developed for treatment of hidradenitis suppurativa (HS). This study will evaluate the efficacy, safety, and immunogenicity of izokibep administered subcutaneously (SC) in adult subjects with moderate to severe HS.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesCanada, Germany, Hungary, Poland, Spain, United States
Collaborators--

Timeline

Phase 2CompletedFinished
2023202420252026
First PostedMay 2, 2022
Enrollment StartMay 5, 2022
Primary CompletionAug 2, 2023
Study CompletionFeb 21, 2024
TodayJul 2, 2026
Enrollment to primary: 1.2 yearsPosted 4.2 years ago

Interventions

Izokibepdrug

Biologic: IL-17A inhibitor Form: Solution for injection Route of administration: Subcutaneous (SC)

Placebo to izokibepdrug

Form: Solution for injection Route of administration: Subcutaneous (SC)