CI

At a glance

ClinicalIndex Comparison Record
Early Ph 1Completed· 26 enrolled
Drug / intervention
particulate xenograft + erythropoietin gel. +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05360511
NCT05360511Early Ph 1Completed
CompareCT.gov

Erythropoietin Gel as an Adjunct to Xenograft in the Surgical Management of Intrabony Periodontal Defects. A Randomized Controlled Clinical Study

Ain Shams University·interventional·Posted May 4, 2022·Updated Jan 16, 2024

In Brief

A Early Phase 1 clinical trial evaluating particulate xenograft + erythropoietin gel. and particulate xenograft for Periodontal Bone Loss. Completed, enrolled 26 participants across 1 site.

Detailed Summary

The aim of the study is to evaluate the use of erythropoietin gel as an adjunct to xenograft in the surgical management of intrabony periodontal defects.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPeriodontal Bone Loss
CountriesEgypt
Collaborators--

Timeline

Early Ph 1CompletedFinished
2023202420252026
First PostedMay 4, 2022
Enrollment StartJul 1, 2022
Primary CompletionSep 1, 2023
Study CompletionOct 1, 2023
TodayJul 2, 2026
Enrollment to primary: 1.2 yearsPosted 4.2 years ago

Interventions

particulate xenograft + erythropoietin gel.drug

1. Surgical sites will be anaesthetized using local anaesthesia. 2. Intrasulcular incision will be done in the periodontal pocket as close as possible to the tooth surface with the deepest point being the alveolar crest. 3. The incisions will be extended to the mesial papilla of the tooth before the defect and the distal papilla of the tooth after the defect. 4. Both buccal and lingual/palatal mucoperiosteal flaps will be raised using blunt dissection. 5. Mechanical debridement of the infected tissue from the intrabony defect and root debridement will be done using Gracey curettes. * In Group A (test group): Particulate xenograft will be mixed with EPO gel and applied to fill the whole defect.

particulate xenograftcombination

* All surgeries will be performed by the same operator as follows: 1. Surgical sites will be anaesthetized using local anaesthesia. 2. Intrasulcular incision will be done in the periodontal pocket as close as possible to the tooth surface with the deepest point being the alveolar crest. 3. The incisions will be extended to the mesial papilla of the tooth before the defect and the distal papilla of the tooth after the defect. 4. Both buccal and lingual/palatal mucoperiosteal flaps will be raised using blunt dissection. 5. Mechanical debridement of the infected tissue from the intrabony defect and root debridement will be done using Gracey curettes. * In Group B (control group): Particulate xenograft will be applied to fill the whole defect.