CI

At a glance

ClinicalIndex Comparison Record
Early Ph 1Completed· 16 enrolled
Drug / intervention
MetFORMIN Oral Solution +3 moredrug
Likely dose
Cimetidine 400 MGfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05365451
NCT05365451Early Ph 1Completed
CompareCT.gov

Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters

Washington State University·interventional·Posted May 9, 2022·Updated Aug 8, 2025

In Brief

A Early Phase 1 clinical trial evaluating MetFORMIN Oral Solution, Cimetidine 400 MG, and 2 other interventions for Interaction and Endogenous Biomarkers. Completed, enrolled 16 participants across 1 site.

Detailed Summary

The objective of this study is to confirm the feasibility of using a panel of endogenous substrates/metabolites as a robust biomarker of OCTs and OATs by conducting a controlled, comprehensive clinical drug-drug interaction study in healthy adult volunteers. Metformin and furosemide will be used as probe drugs for OCTs and OATs, respectively; cimetidine and probenecid will be used as corresponding inhibitors. Results from this study will validate this novel approach, which will be extended to children by collaborators at Children's Mercy Hospital in Kansas City, MO.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsInteraction, Endogenous Biomarkers
CountriesUnited States
CollaboratorsEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)

Timeline

Early Ph 1CompletedFinished
2023202420252026
First PostedMay 9, 2022
Enrollment StartApr 11, 2022
Primary CompletionJul 22, 2023
TodayJul 2, 2026
Enrollment to primary: 1.3 yearsPosted 4.1 years ago

Interventions

MetFORMIN Oral Solutiondrug

liquid

Cimetidine 400 MGdrug

tablet

Furosemide Oral Liquid Productdrug

oral solution

Probenecid 500 MGdrug

tablet