CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 90 enrolled
Drug / intervention
Quadruple combination of half doses therapy→Dual combination of standard dose therapy +1 moredrug
Likely dose
Quadruple combination of half doses therapy→Dual combination of standard dose therapy 2.5mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05377203
NCT05377203Phase 4Completed
CompareCT.gov

Initial Treatment With a Single Capsule Containing Quadruple Combination of Half Doses of Blood Pressure Medicines Versus Standard Dose Dual Therapy in Patients With Hypertension: A Single-center, Randomized, Double-blind, Crossover Trial

The Third Xiangya Hospital of Central South University·interventional·Posted May 17, 2022·Updated Jul 18, 2023

In Brief

A Phase 4 clinical trial evaluating Quadruple combination of half doses therapy→Dual combination of standard dose therapy and Dual combination of standard dose therapy→ Quadruple combination of half doses therapy for Hypertension and Arterial Hypertension. Completed, enrolled 90 participants across 1 site.

Detailed Summary

This study aims to compare the antihypertensive effect of initial treatment with a single capsule containing quadruple combination of half-dose of blood pressure medicines or standard dose dual combination in patients with hypertension.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHypertension, Arterial Hypertension
CountriesChina
Collaborators--

Timeline

Phase 4CompletedFinished
2023202420252026
First PostedMay 17, 2022
Enrollment StartJul 13, 2022
Primary CompletionJul 4, 2023
TodayJul 2, 2026
Enrollment to primary: 12 monthsPosted 4.1 years ago

Interventions

Quadruple combination of half doses therapy→Dual combination of standard dose therapydrug

Quadruple combination of half doses therapy: a single capsule containing quadruple combination of half doses of blood pressure medicines (amlodipine besylate tablet 2.5mg, amlodipine besylate tablet simulator 2.5mg, irbesartan tablets 75mg, irbesartan tablets simulator 75mg, metoprolol succinate sustained-release tablets 23.75mg, indapamide tablets 1.25mg), take orally, one capsule once a day. Dual combination of standard dose therapy: a single capsule containing dual combination of standard dose of blood pressure medicines (amlodipine besylate tablets 2.5mg×2, irbesartan tablets 75mg×2, metoprolol succinate sustained-release tablets simulator 23.75mg, indapamide tablets simulator 1.25mg), take orally, one capsule once a day.

Dual combination of standard dose therapy→ Quadruple combination of half doses therapydrug

Dual combination of standard dose therapy: a single capsule containing dual combination of standard dose of blood pressure medicines (amlodipine besylate tablets 2.5mg×2, irbesartan tablets 75mg×2, metoprolol succinate sustained-release tablets simulator 23.75mg, indapamide tablets simulator 1.25mg), take orally, one capsule once a day. Quadruple combination of half doses therapy: a single capsule containing quadruple combination of half doses of blood pressure medicines (amlodipine besylate tablet 2.5mg, amlodipine besylate tablet simulator 2.5mg, irbesartan tablets 75mg, irbesartan tablets simulator 75mg, metoprolol succinate sustained-release tablets 23.75mg, indapamide tablets 1.25mg), take orally, one capsule once a day.