At a glance
ClinicalIndex Comparison Record- ✓Histologically confirmed malignant illness
- ✓4-15 suspect intracranial lesions on MRI
- ✓Age ≥18 years
- ✓Adequate contraception for women of childbearing potential and men
- ✕Refusal to participate
- ✕Inability to tolerate irradiation per protocol
- ✕Small-cell lung cancer (SCLC) or lymphoma as primary malignancy
- ✕>15 suspect intracranial lesions
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
The CyberChallenge Trial How Much is Too Much - What is the Role of Cyberknife Radiosurgery in Patients With Multiple Brain Metastases?
In Brief
A clinical study evaluating SRS and Whole Brain Radiotherapy for Brain Metastases and Nsclc. Currently recruiting, targeting 190 participants across 1 site.
Detailed Summary
Patients suffering from malignancies in advanced stages often develop brain metastases, which limit both the life span and the quality of life. Therapy options for multiple brain metastases may vary and range from stereotactic radiosurgery (SRS), whole-brain radiotherapy (WBRT), chemotherapy, immunotherapy to palliative best supportive care. Especially the efficacy and toxicity of SRS compared to WBRT in patients with extensive brain metastases (\>4) is not yet clear but of incremental relevance in this seriously ill cohort with a limited life span. These health-impaired patients might especially profit from a less toxic treatment that is also time sparing with 1 or few sessions in SRS versus 10 sessions in WBRT. On the other hand, no compromises in efficacy want to be done.
Study Details
Timeline
Interventions
Stereotactic Radiotherapy (SRS)
Whole Brain Radiotherapy (WBRT)