CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 40 enrolled
Drug / intervention
transcutaneous auricular vagal nerve stimulation +1 moredevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05390580
NCT05390580N/ACompleted

Neuromodulation Using Vagus Nerve Stimulation Following Ischemic Stroke as Therapeutic Adjunct

Washington University School of Medicine·interventional·Posted May 25, 2022·Updated Oct 31, 2025

In Brief

A clinical study evaluating transcutaneous auricular vagal nerve stimulation and Sham transcutaneous vagal nerve stimulation for Acute Ischemic Stroke. Completed, enrolled 40 participants across 1 site.

Detailed Summary

This is a randomized open-label, with blinded outcome pilot study to evaluate the effect on inflammatory laboratory values and explore clinical outcomes in patients who present with ischemic strokes due to large vessel occlusions and are treated with either current accepted management, or accepted management in addition to transcutaneous auricular vagal nerve stimulation.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
2023202420252026
First PostedMay 25, 2022
Enrollment StartSep 26, 2022
Primary CompletionAug 23, 2024
TodayJul 2, 2026
Enrollment to primary: 1.9 yearsPosted 4.1 years ago

Interventions

transcutaneous auricular vagal nerve stimulationdevice

Stimulus of the auricular branch of the vagal nerve with the transcutaneous auricular vagal nerve stimulation.

Sham transcutaneous vagal nerve stimulationdevice

Patients assigned to the controls arm will have no electricity applied to the Auricular Branch of the Vagus Nerve. Stimulus will be provided to the lobule of the ear, which is not innervated by the Auricular Branch of the Vagus Nerve.