CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 313 enrolled
Drug / intervention
N-back +2 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05396586
NCT05396586N/ACompleted

Assessment and Training of Cognitive Function

Northeastern University·interventional·Posted May 31, 2022·Updated Mar 12, 2025

In Brief

A clinical study evaluating N-back, Span, and 1 other intervention for Cognitive Change. Completed, enrolled 313 participants across 2 sites.

Detailed Summary

The present study investigates how individual differences in cognitive processing contribute to the efficacy of working memory training programs in an older adult population. In a randomized crossover design, different types of working memory training interventions will be evaluated within the same participants. Adding game-like elements to working memory training programs can increase motivation and engagement, which can increase learning. However this process, termed gamification, adds sensory complexity that can lead to increased mental load and/or distraction in older adults. Investigators hypothesize that gamification of training tasks will be beneficial to some and counterproductive to other participants. The investigators will test two models; the first assumes that participants with difficulty inhibiting distracting information will show better learning and transfer when assigned to non-gamified training, whereas those with more distractor tolerance will show better learning and transfer when assigned to gamified training. The second model states that the outcomes of the intervention will be better predicted by performance on measures of general cognitive ability. In a separate study, the investigators will compare working memory training that contains rich, multisensory information with a training program that contains only visual information. Here they will also test two models; the first assumes that participants with difficulty binding two stimulus streams will show better learning and transfer when assigned to visual-only working memory training, whereas participants who do not have this difficulty will show better learning and transfer when assigned to multisensory working memory training. The second model states that the outcomes of the intervention will be better predicted by performance on measures of general cognitive ability.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

N/ACompletedFinished
2023202420252026
First PostedMay 31, 2022
Enrollment StartMar 17, 2022
Primary CompletionMar 5, 2025
TodayJul 2, 2026
Enrollment to primary: 3.0 yearsPosted 4.1 years ago

Interventions

N-backbehavioral

The training program is a personal device-based adaptive version of a visual N-back task, either devoid of game elements or embedded in a gamified platform game

Spanbehavioral

The training program is a personal device-based adaptive version of a visual working memory span task, either devoid of game elements or embedded in a gamified platform game

Multisensorybehavioral

The training program is a personal device-based adaptive version of an N-back task that features visual stimuli (Unisensory) or visual stimuli paired with unique sounds (Multisensory) and is devoid of game elements