At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Understanding Circadian Responses to Light in Persons With Mild Cognitive Impairment and Alzheimer's Disease
In Brief
A clinical study evaluating Lighting Intervention Blue light, Lighting Intervention Green light, and 1 other intervention for Mild Cognitive Impairment and Alzheimer Disease. Completed, enrolled 36 participants across 1 site.
Detailed Summary
The purpose of this research study is to investigate the relationship between light, the thickness of the pigment at the back of your eye, melatonin levels, and memory. The study will investigate whether changing light distribution pattern from "on-axis"' (i.e., directed along the eye's visual axis to the fovea) to "off-axis" (i.e., directed on the periphery of the eye's visual axis) impact melatonin suppression in 24 mild cognitive impairment participants and 24 healthy, age-matched controls.
Study Details
Timeline
Interventions
Custom made lighting fixture that will deliver the blue lighting intervention. Blue light (λmax = 451 nm) on axis and off axis.
Custom made lighting fixture that will deliver the green lighting intervention. Green light (λmax = 522 nm) on and off axis
(\< 5 lux at the eye) for 30 min