CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 26 enrolled
Drug / intervention
Transcranial magnetic stimulation (TMS)device
Likely dose
TMS applied at peaks or troughs of ongoing prefrontal theta oscillations (3–7 Hz) concurrently with cognitive testing at the beginning of every test trialAI-extracted
Key inclusion· 2
  • ✓Age 18–65 years old
  • ✓Fluent English speaker
Key exclusion· 5
  • ✕Chronic condition requiring pharmacological treatment during study
  • ✕Metallic or electric implant in head, neck, or chest, or MRI-noncompatible implants
  • ✕History or evidence of seizures, head injury with loss of consciousness, or chronic neurological/mental disorder
  • ✕Pregnancy or breastfeeding

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05416138
NCT05416138N/ACompleted
CompareCT.gov

The Effects of Closed-loop TMS-EEG on Immediate Prefrontal Activity and Approach/Avoidance Behavior

University of Minnesota·interventional·Posted Jun 13, 2022·Updated Dec 10, 2025

In Brief

A clinical study evaluating Transcranial magnetic stimulation (TMS) for Approach/Avoidance Behavior. Completed, enrolled 26 participants across 1 site.

Detailed Summary

The purpose of this study is to evaluate the causal link between the phase of ongoing theta oscillations in the prefrontal cortex and approach/avoidance (Ap/Av) behavior in adults using theta phase-specific transcranial magnetic stimulation (TMS).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsApproach/Avoidance Behavior
CountriesUnited States
CollaboratorsNational Institute of Mental Health (NIMH)

Timeline

N/ACompletedFinished
2023202420252026
First PostedJun 13, 2022
Enrollment StartNov 1, 2022
Primary CompletionAug 31, 2024
TodayJul 2, 2026
Enrollment to primary: 1.8 yearsPosted 4.1 years ago

Interventions

Transcranial magnetic stimulation (TMS)device

TMS will be performed at either peaks or troughs of ongoing prefrontal theta oscillations (3-7 Hz) concurrently with the cognitive test at the beginning of every test trial. Theta oscillations will be monitored in real-time at the left dorsolateral prefrontal cortex using electroencephalography (EEG).