CI

At a glance

ClinicalIndex Comparison Record
Phase 1Completed· 40 enrolled / 40 target
Drug / intervention
Radiotracerdrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05418608
NCT05418608Phase 1CompletedOn Track (0.8/mo)Completion was 27mo ago
CompareCT.gov

Novel in Vivo Synaptic Imaging in Experienced Meditators

Yale University·interventional·Posted Jun 14, 2022·Updated Jun 10, 2026

In Brief

A Phase 1 clinical trial evaluating Radiotracer for Behavior, Health. Completed, enrolled 40 participants across 1 site.

Detailed Summary

To utilize positron emission tomography (PET) imaging to characterize the distribution of (aka \[11C\]APP311at the Yale PET Center) in cortical and subcortical areas in experienced meditators compared to non-meditating controls.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsBehavior, Health
CountriesUnited States
CollaboratorsNational Center for Complementary and Integrative Health (NCCIH)

Timeline

Phase 1CompletedFinished
2023202420252026
First PostedJun 14, 2022
Enrollment StartApr 21, 2022
Primary CompletionApr 1, 2024
TodayJul 2, 2026
Enrollment to primary: 1.9 yearsPosted 4.0 years ago

Arms & Interventions

Meditatorsexperimental

A PET study of the novel SV2A imaging tracer \[11C\]UCB-J in participants, to characterize the distribution of \[11C\]UCB-J in cortical and subcortical areas in experienced meditators compared to non-meditating controls. Subjects will undergo one PET scan with \[11C\]UCB-J and one MRI scan for anatomical identification of brain regions.

Drug: Radiotracer
Non-meditating controlsactive_comparator

Meditators compared to non-meditating controls. Subjects will undergo one PET scan with \[11C\]UCB-J and one MRI scan for anatomical identification of brain regions.

Drug: Radiotracer

Interventions

Radiotracerdrug

A novel SV2A imaging tracer which is used in conjunction with positron emission tomography scans.