CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 118,562 enrolled
Drug / intervention
Arm 1: Routine Care +1 moreother
Likely dose
Not stated in record
Key inclusion· 4
  • ✓HCA Healthcare hospital admitting adults for skin and soft tissue infection
  • ✓Hospital use of MEDITECH electronic health record system
  • ✓Adult patients age ≥18 admitted to non-intensive care unit wards
  • ✓Patients ordered to receive extended-spectrum antibiotics for skin and soft tissue infection
Key exclusion· 0

None specified.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

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NCT05423756N/ACompleted
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The INSPIRE-ASP Trial (INtelligent Stewardship Prompts to Improve Real-Time Empiric Antibiotic Selection for Patients) for Skin and Soft Tissue (SST) Infections

Harvard Pilgrim Health Care·interventional·Posted Jun 21, 2022·Updated Aug 26, 2025

In Brief

A clinical study evaluating Arm 1: Routine Care and Arm 2: INSPIRE Stewardship Bundle for Skin and Soft Tissue Infection for Skin and Soft Tissue (SST) Infection. Completed, enrolled 118,562 participants across 102 sites.

Detailed Summary

The INSPIRE Skin and Soft Tissue Infection trial is a cluster-randomized controlled trial of HCA Healthcare hospitals comparing routine empiric antibiotic stewardship practices with real-time, precision medicine computerized physician order entry (CPOE) smart prompts providing the probability that a non-critically ill adult admitted with skin and soft tissue infection is infected with a resistant pathogen. Note: enrolled "subjects" represent 102 individual HCA Healthcare hospitals that have been randomized into 92 clusters. Hospitals were grouped into the same randomization cluster if they shared campuses or antibiotic stewardship staff.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsSkin and Soft Tissue (SST) Infection
CountriesUnited States
CollaboratorsHospital Corporation of America, University of California, Irvine, University of Massachusetts, Amherst, Brigham and Women's Hospital, Rush University

Timeline

N/ACompletedFinished
2023202420252026
First PostedJun 21, 2022
Enrollment StartJan 1, 2023
Primary CompletionMay 9, 2024
TodayJul 2, 2026
Enrollment to primary: 1.4 yearsPosted 4.0 years ago

Interventions

Arm 1: Routine Careother

Routine Antibiotic Stewardship Arm - Continuation of antibiotic stewardship activities in accordance with national standards.

Arm 2: INSPIRE Stewardship Bundle for Skin and Soft Tissue Infectionother

Quality improvement intervention that includes (1) computerized physician order entry (CPOE) decision support alert that provides physicians with patient-specific risk estimates for having a skin/soft tissue infection due to a multidrug-resistant organism (MDRO) and recommends standard spectrum antibiotics for low risk patients in the first 3 days of hospitalization; (2) clinician feedback reports, and (3) activities to support CPOE adoption (including education and alignment of CPOE workflows). Other antibiotic stewardship activities to continue in accordance with national standards.