CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 48 enrolled
Drug / intervention
Autism-adapted Group Cognitive Behavioral Therapybehavioral
Likely dose
Not stated in record
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Search/NCT05430022
NCT05430022N/ACompleted

Adapted Cognitive Behavioral Therapy for Depression in Autistic Youth: A Pilot Trial

Vanderbilt University Medical Center·interventional·Posted Jun 24, 2022·Updated Nov 8, 2024

In Brief

A clinical study evaluating Autism-adapted Group Cognitive Behavioral Therapy for Autism Spectrum Disorder and 3 related conditions. Completed, enrolled 48 participants across 1 site.

Detailed Summary

Higher rates of depression are reported by autistic adolescents as compared to their non-autistic peers, which is problematic given adverse outcomes (e.g., negative self-esteem, lower academic performance) that are associated with depression. Despite the alarming rates of depression in autistic youth and associated safety concerns, few treatments have been developed. In this study, we investigate the feasibility, acceptability, and preliminary efficacy of an autism-adapted group cognitive-behavioral treatment for autistic adolescents (11-17 years old; middle and high school) in a pilot, nonrandomized trial. Specifically, we aim to increase adolescents' perception and understanding of self, including autistic identity, in order to treat depression. Intervention design and implementation were guided by autistic self-advocates and parents.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
20222023202420252026
First PostedJun 24, 2022
Enrollment StartJul 21, 2021
Primary CompletionFeb 3, 2023
Study CompletionApr 3, 2023
TodayJul 2, 2026
Enrollment to primary: 1.5 yearsPosted 4.0 years ago

Interventions

Autism-adapted Group Cognitive Behavioral Therapybehavioral

The autism-adapted Group Cognitive Behavioral Therapy (CBT) was designed by the PI and research team in collaboration with autistic stakeholders (i.e., adults, parents, researchers). It is a 12-week group intervention (90 min) delivered on a weekly basis in an outpatient psychiatry clinic by licensed clinical psychologists and psychology trainees. Each group is comprised of 8-9 autistic adolescents (11-17 years old; middle and high school) with depression. The intervention targets adolescents' perception and understanding of self, including autistic identity, through a series of cognitive-behavioral approaches including psychoeducation, emotion regulation, cognitive distortions, cognitive restructuring, behavioral rehearsals, and weekly homework assignments.