At a glance
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Serum Prolidase Activity in Primary Ovarian Insufficiency
In Brief
An observational study evaluating Prolidase Level, Follicle Stimulating Hormone Level, and 7 other interventions for Oxidative Stress and 2 related conditions. Completed, enrolled 133 participants across 1 site.
Detailed Summary
Primary Ovarian Insufficiency (POI) is dysfunction of ovaries before 40 years of age. It has been reported that genetic factors, endocrine disorders, previous pelvic surgeries, chemotherapy and radiotherapy, and autoimmune mechanisms play a role in 10%, however the etiology has not been clarified in 90% of the cases. Oxidative stress and autoimmunity has been shown to be responsible in the etiopathogenesis of POI. Prolidase is an imidodipeptidase. Prolidase was shown to be related with oxidative stress and autoimmune diseases in previous studies. In addition, it is thought that the level of prolidase plays a role both in the etiopathogenesis and progression of diseases. This study aims to investigate the level of prolidase enzyme in women with POI.
Study Details
Timeline
Interventions
Measurement of venous blood serum level of prolidase enzyme level by ELISA method.
Measurement of venous blood serum level of follicle stimulating hormone level.
Measurement of venous blood serum level of estradiol hormone level.
Measurement of venous blood serum level of proline level.
Measurement of venous blood serum level of hydroxyproline level.
Measurement of venous blood serum level of anti-mullerian hormone level.
Ultrasonographic evaluation of antral follicle count to determine ovarian reserve.
Measurement of venous blood serum prolactine hormone level.
Measurement of venous blood serum thyroid stimulating hormone level.