CI

At a glance

ClinicalIndex Comparison Record
Phase 1Completed· 72 enrolled
Drug / intervention
MK-6194 +1 morebiological
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05450198
NCT05450198Phase 1Completed

A Randomized, Double-Blind, Placebo-Controlled, Multiple Rising Dose Clinical Trial to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MK-6194 in Participants With Moderate to Severe Atopic Dermatitis

Merck Sharp & Dohme LLC·interventional·Posted Jul 8, 2022·Updated Jun 5, 2025

In Brief

A Phase 1 clinical trial evaluating MK-6194 and Placebo for Dermatitis, Atopic. Completed, enrolled 72 participants across 19 sites in 6 countries.

Detailed Summary

The primary objective of this study is to characterize the safety and tolerability of MK-6194 following multiple doses among participants with moderate to severe atopic dermatitis who are unresponsive to other therapies.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesBelgium, Bulgaria, Canada, Romania, Spain, United States
Collaborators--

Timeline

Phase 1CompletedFinished
2023202420252026
First PostedJul 8, 2022
Enrollment StartAug 8, 2022
Primary CompletionMay 22, 2024
TodayJul 2, 2026
Enrollment to primary: 1.8 yearsPosted 4.0 years ago

Interventions

MK-6194biological

MK-6194 administered subcutaneously (SC)

Placebobiological

Placebo comparator to MK-6194 administered SC