CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 68 enrolled
Drug / intervention
VVN539 Ophthalmic Solution 0.02% +2 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05451329
NCT05451329Phase 2Completed
CompareCT.gov

A Phase 2, Double-masked, Randomized, Vehicle-controlled, Dose-response Study Assessing the Safety and Ocular Hypotensive Efficacy of VVN539 in Subjects With Primary Open Angle Glaucoma or Ocular Hypertension

VivaVision Biotech, Inc·interventional·Posted Jul 11, 2022·Updated Jan 17, 2024

In Brief

A Phase 2 clinical trial evaluating VVN539 Ophthalmic Solution 0.02%, VVN539 Ophthalmic Solution 0.04%, and 1 other intervention for Glaucoma, Open-Angle. Completed, enrolled 68 participants across 1 site.

Detailed Summary

This is a prospective, parallel-comparison, multi-center, double-masked, randomized, vehicle-controlled dose-response study assessing the safety and ocular hypotensive efficacy of VVN539 in subjects with POAG or OHT. Three different dosing regimens (once a day \[q.d.\] in the morning, q.d. in the evening and twice a day \[b.i.d.\]) will be tested for 7-9 days, each.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsGlaucoma, Open-Angle
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
2023202420252026
First PostedJul 11, 2022
Enrollment StartJul 12, 2022
Primary CompletionDec 22, 2022
TodayJul 2, 2026
Enrollment to primary: 5 monthsPosted 4.0 years ago

Interventions

VVN539 Ophthalmic Solution 0.02%drug

Once a day \[q.d.\] in the morning, q.d. in the evening and twice a day \[b.i.d.\]) will be tested for 7-9 days

VVN539 Ophthalmic Solution 0.04%drug

Once a day \[q.d.\] in the morning, q.d. in the evening and twice a day \[b.i.d.\]) will be tested for 7-9 days

VVN539 Ophthalmic Solution Vehicledrug

Once a day \[q.d.\] in the morning, q.d. in the evening and twice a day \[b.i.d.\]) will be tested for 7-9 days