CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 608 enrolled
Drug / intervention
Eptinezumab +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05452239
NCT05452239Phase 4Completed

Interventional, Randomized, Double-blind, Parallel-group, Placebo-controlled Study of add-on Eptinezumab Treatment to Brief Educational Intervention for the Preventive Treatment of Migraine in Patients With Dual Diagnosis of Migraine and Medication Overuse Headache

H. Lundbeck A/S·interventional·Posted Jul 11, 2022·Updated Jan 29, 2026

In Brief

A Phase 4 clinical trial evaluating Eptinezumab and Placebo for Migraine and Medication Overuse Headache. Completed, enrolled 608 participants across 76 sites in 11 countries.

Detailed Summary

Medication overuse headache (MOH) is a type of headache caused by excessive use of acute headache or migraine medications (medications used to treat a headache or migraine once it begins). Treatment of MOH usually involves reducing the dose of or discontinuing acute medications. Eptinezumab is a medication used for the preventive treatment of migraine in adults. The main goals of this trial are to learn whether eptinezumab helps reduce the number of days with migraine, the number of days with headache, and acute medication use in adults who have migraine and MOH.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesAustralia, Denmark, France, Georgia, Germany, Italy, Netherlands, Norway, Spain, Sweden, United States
Collaborators--

Timeline

Phase 4CompletedFinished
2023202420252026
First PostedJul 11, 2022
Enrollment StartJul 1, 2022
Primary CompletionOct 22, 2024
Study CompletionMar 13, 2025
TodayJul 2, 2026
Enrollment to primary: 2.3 yearsPosted 4.0 years ago

Interventions

Eptinezumabdrug

Solution for infusion

Placebodrug

Solution for infusion