CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 71 enrolled
Drug / intervention
Vitamin D 2 +1 moredrug
Likely dose
Vitamin D 2 50,000 IUfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05458024
NCT05458024Phase 2Completed
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Randomized Controlled Trial of Vitamin D to Reduce Racial Disparity in Chronic Pain Following Motor Vehicle Collision

University of North Carolina, Chapel Hill·interventional·Posted Jul 14, 2022·Updated Mar 28, 2025

In Brief

A Phase 2 clinical trial evaluating Vitamin D 2 and Vitamin D2 Placebo for Musculoskeletal Pain. Completed, enrolled 71 participants across 4 sites.

Detailed Summary

The main objective of this study is to determine whether the administration of a single dose of Vitamin D in the Emergency Department following a motor vehicle collision can improve musculoskeletal pain severity as well as reduce musculoskeletal pain outcome disparity between Blacks and White following a motor vehicle collision. This randomized controlled trial is a pilot study to determine feasibility and potential efficacy (response to study drug, ability to reduce racial disparity in pain outcomes). This data can be used to adequately power a larger randomized controlled trial to fully assess efficacy.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMusculoskeletal Pain
CountriesUnited States
CollaboratorsNational Institute on Minority Health and Health Disparities (NIMHD)

Timeline

Phase 2CompletedFinished
2023202420252026
First PostedJul 14, 2022
Enrollment StartJan 24, 2023
Primary CompletionMay 1, 2024
TodayJul 2, 2026
Enrollment to primary: 1.3 yearsPosted 4.0 years ago

Interventions

Vitamin D 2drug

300,000 international units (IUs) of Ergocalciferol in 6 50,000 IU capsules.

Vitamin D2 Placebodrug

Inert substance will be administered in 6 capsules indistinguishable from the 50,000 IU