CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 530 enrolled
Drug / intervention
Methylprednisolone +1 moredrug
Likely dose
Methylprednisolone 250 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05462730
NCT05462730Phase 2Completed
CompareCT.gov

Pulse Glucocorticoid Therapy in Patients With ST-Segment Elevation Myocardial Infarction

Thomas Engstrom·interventional·Posted Jul 18, 2022·Updated Mar 27, 2026

In Brief

A Phase 2 clinical trial evaluating Methylprednisolone and Isotonic saline for ST Elevation Myocardial Infarction and 3 related conditions. Completed, enrolled 530 participants across 1 site.

Detailed Summary

The overall primary objective of the PULSE-MI trial is to test the hypothesis that administration of single-dose glucocorticoid pulse therapy in the pre-hospital setting reduces final infarct size in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI)

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsST Elevation Myocardial Infarction, Inflammatory Response, Myocardial Reperfusion Injury, Myocardial Injury
CountriesDenmark
Collaborators--

Timeline

Phase 2CompletedFinished
2023202420252026
First PostedJul 18, 2022
Enrollment StartNov 14, 2022
Primary CompletionJan 30, 2024
Study CompletionOct 17, 2024
TodayJul 2, 2026
Enrollment to primary: 1.2 yearsPosted 4.0 years ago

Interventions

Methylprednisolonedrug

A dosis of 250 mg methylprednisolone is suspended in isotonic saline to a total volume of 4 mL prior to infusion.

Isotonic salinedrug

A bolus infusion of 4 mL isotonic saline (NaCl 0.9%).