CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 730 enrolled
Drug / intervention
Insulin Efsitora Alfa +2 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05462756
NCT05462756Phase 3Completed

A Phase 3, Parallel-Design, Open-Label, Randomized Controlled Study to Evaluate the Efficacy and Safety of LY3209590 as a Weekly Basal Insulin Compared to Insulin Glargine in Adults With Type 2 Diabetes on Multiple Daily Injections

Eli Lilly and Company·interventional·Posted Jul 18, 2022·Updated Apr 27, 2025

In Brief

A Phase 3 clinical trial evaluating Insulin Efsitora Alfa, Insulin Lispro (U100), and 1 other intervention for Type 2 Diabetes and Type 2 Diabetes Treated With Insulin. Completed, enrolled 730 participants across 81 sites in 8 countries.

Detailed Summary

The reason for this study is to evaluate if the once-weekly study drug insulin efsitora alfa (LY3209590) is safe and effective compared with daily insulin glargine in participants with Type 2 diabetes (T2D) that have already been treated with basal insulin and at least 2 injections per day of prandial insulin. The study consists of a 3-week screening/lead-in period, a 26-week treatment period and a 5-week safety follow-up period. The study will last up to 34 weeks.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesArgentina, Germany, India, Italy, Mexico, Puerto Rico, Spain, United States
Collaborators--

Timeline

Phase 3CompletedFinished
2023202420252026
First PostedJul 18, 2022
Enrollment StartAug 11, 2022
Primary CompletionFeb 27, 2024
TodayJul 2, 2026
Enrollment to primary: 1.5 yearsPosted 4.0 years ago

Interventions

Insulin Efsitora Alfadrug

Administered SC

Insulin Lispro (U100)drug

Administered SC

Insulin Glargine (U100)drug

Administered SC