At a glance
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Does Tranexamic Acid Reduce the Need for Deliberate Hypotensive Anesthesia Within Orthognathic Surgery? A Prospective Study
In Brief
A Phase 4 clinical trial evaluating Avoidance of Deliberate Hypotensive Anesthesia and TRANEXAMIC ACID 1 G in 10 mL INTRAVENOUS INJECTION, SOLUTION for Hypotension During Surgery and Blood Loss, Surgical. Completed, enrolled 115 participants across 1 site.
Detailed Summary
This prospective study will analyze the need for deliberate hypotensive anesthesia (DHA) during orthognathic surgery when tranexamic acid (TXA) is administered. DHA has been proven to be effective although it comes with multiple risks related to organ hypoperfusion including kidney injury, stroke, and cardiac ischemia. Therefore, it may be potentially safer for patients to avoid deliberate hypotensive anesthesia if TXA alone adequately controls blood loss and provides adequate surgical site visualization.
Study Details
Timeline
Interventions
The anesthesia team will be asked to avoid deliberate hypotensive anesthesia and maintain blood pressure closer to the patient's baseline throughout the surgery.
1g of tranexamic acid will be given intravenously to patient undergoing orthognathic surgery as routinely performed about 5-15 minutes before first surgical incision.