CI

At a glance

ClinicalIndex Comparison Record
Phase 4Active· 83 enrolled
Drug / intervention
Celecoxib +11 moredrug
Likely dose
Oxycodone Hydrochloride 5 Mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05488847
NCT05488847Phase 4Active

Multimodal Nonopioid Pain Protocol Following Shoulder Arthroplasty Surgery

Henry Ford Health System·interventional·Posted Aug 5, 2022·Updated Feb 10, 2026

In Brief

A Phase 4 clinical trial evaluating Celecoxib, Pregabalin, and 10 other interventions for Shoulder Arthropathy and Shoulder Pain. Active but no longer recruiting, targeting 83 participants across 1 site.

Detailed Summary

This randomized, single blinded, clinical trial aims to investigate the efficacy of a multimodal pain control regimen for shoulder arthroplasty. Patients who receive a multimodal pain control regimen alone (study group) will be compared to patients who receive a multimodal pain control regimen plus a standard prescription of an opioid containing medication (comparison group). The primary outcome is average daily Numerical Rating Scale (NRS) pain score in the first 10 days after surgery. We hypothesize that there will be no significant difference in the primary outcome between the two groups.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

Phase 4Active
2023202420252026
First PostedAug 5, 2022
Enrollment StartJun 25, 2022
Primary CompletionDec 11, 2024
Study CompletionSep 1, 2026
TodayJul 2, 2026
Enrollment to primary: 2.5 yearsPosted 3.9 years ago

Interventions

Celecoxibdrug

preoperative pain medication given to all patients

Pregabalindrug

preoperative and discharge pain medication given to all patients

Tramadoldrug

preoperative pain medication given to all patients

Dexamethasonedrug

Intraoperative and discharge pain medication given to all patients

Acetaminophendrug

Intraoperative and discharge pain medication given to all patients

Ropivicainedrug

Intraoperative pain medication given to all patients

Epinephrinedrug

Intraoperative pain medication given to all patients

Ketorolacdrug

Intraoperative pain medication given to all patients

Tizanidinedrug

Discharge pain medication given to all patients

Magnesiumdrug

Discharge pain medication given to all patients

Ibuprofendrug

Discharge pain medication given to all patients

Oxycodone Hydrochloride 5 Mgdrug

Only given to active comparator group