At a glance
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Ultrasonic Deep Brain Stimulation During Anesthetic Sedation
In Brief
A Phase 2 clinical trial evaluating Low-intensity focused ultrasound pulsation (LIFUP) and Functional Magnetic Resonance Imaging (fMRI) using Propofol for Mental Function. Completed, enrolled 13 participants across 1 site.
Detailed Summary
The purpose of this study is to see if mental functions take place during different levels of anesthesia. The researchers expect to gain a deeper understanding of mental function during different levels of anesthesia, and to evaluate if the use of ultrasonic brain stimulation accelerates return to consciousness.
Study Details
Timeline
Interventions
LIFUP will be used to stimulate specific brain regions and assess their causal involvement in the control of conscious state and contents.
Propofol will be administered by intravenous infusion. All anesthesia equipment, supplies, and drugs will be provided by anesthesiologists from the University of Michigan Health System. The researchers will manually control the infusion of propofol to achieve target effect-site concentrations