CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 28 enrolled
Drug / intervention
Experimental: Modified minimally invasive surgical technique with PRF and vitamins A and C +1 moreprocedure
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05499598
NCT05499598N/ACompleted
CompareCT.gov

Clinical and Radiographic Evaluation of Modified Minimally Invasive Surgical Technique and Platelet Rich Fibrin With or Without Vitamin Pool A and C for Management of Periodontal Intrabony Defects: A Randomized Controlled Clinical Trial

Cairo University·interventional·Posted Aug 12, 2022·Updated Apr 22, 2026

In Brief

A clinical study evaluating Experimental: Modified minimally invasive surgical technique with PRF and vitamins A and C and Modified minimally invasive surgical technique with PRF for Intrabony Periodontal Defect. Completed, enrolled 28 participants across 1 site.

Detailed Summary

This study aims to assess clinical and radiographic outcomes after the use of vitamins A and C with PRF versus PRF alone in the treatment of periodontal intrabony defect.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsIntrabony Periodontal Defect
CountriesEgypt
Collaborators--

Timeline

N/ACompletedFinished
2023202420252026
First PostedAug 12, 2022
Enrollment StartSep 1, 2022
Primary CompletionApr 1, 2024
Study CompletionMay 30, 2024
TodayJul 2, 2026
Enrollment to primary: 1.6 yearsPosted 3.9 years ago

Interventions

Experimental: Modified minimally invasive surgical technique with PRF and vitamins A and Cprocedure

Surgical technique (M-MIST) with the same procedures will be performed. Approximately 10 mm of fresh blood will be drawn by venipuncture of the antecubital vein and collected into a blood collection tube without anticoagulant. Ascorbic Acid will be added to the fresh blood to achieve a concentration of 250 μg/ml, Retinol will also be added to achieve a concentration of 20 μmol/L. The resultant PRF clot will be placed into the intra-osseous defect.

Modified minimally invasive surgical technique with PRFprocedure

Surgical technique (M-MIST) with the same procedures will be performed. Approximately 10 mm of fresh blood will be drawn by venipuncture of the antecubital vein and collected into a blood collection tube without anticoagulant. The resultant PRF clot will be placed into the intra-osseous defect.