At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Longitudinal Changes in Muscle Mass After Intensive Care: a Pilot Feasibility Study.
In Brief
A clinical study evaluating Muscle ultrasound, Indirect calorimetry, and 2 other interventions for Critical Illness and Muscle Loss. Completed, enrolled 35 participants across 1 site.
Detailed Summary
Critically ill patients often suffer from dramatic muscle loss while in the ICU. Recovery of muscle structure and function have been proposed as core outcome measures for interventional studies in ICU survivors. Ultrasound is an accessible and validated tool to monitor muscle mass over time, with quadriceps muscle layer thickness (MLT) corresponding well to more invasive or cumbersome modalities. In order to design adequately powered studies investigating the effects of nutritional or metabolic interventions on post-ICU recovery, an estimate of the population standard deviation in MLT change over time is required. Currently there is a paucity of data describing changes in muscle mass during the subsequent period of hospitalization in ICU survivors. The aim of this study is to estimate the mean change and standard deviation in quadriceps MLT over time, in patients discharged alive from intensive care. Patients will be followed until hospital discharge or up to 28 days after ICU discharge. Interactions with nutritional intake, inflammation and metabolic rate will be analyzed for hypothesis-generating purposes.
Study Details
Timeline
Interventions
Standardized ultrasonographic measurement of quadriceps muscle layer thickness.
Non-invasive measurement of resting energy expenditure using the Q-NRG metabolic monitor with hood and canopy.
Assessment of handgrip strength using hand dynamometry.
Assessment of muscle function/limb strength using the Medical Research Council sum score (12-60 points).