At a glance
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The Effect of Non-surgical Periodontal Treatment on Serum and Gingival Crevicular Fluid Periostin Levels
In Brief
A clinical study evaluating Non-surgical periodontal treatment for Periodontal Treatment, Cytokines. Completed, enrolled 48 participants across 1 site.
Detailed Summary
Two different studies were planned from the recruited samples. The aim of these studies was to investigate the effect of non-surgical periodontal treatment on the inflammatory markers levels in serum and gingival crevicular fluid (GCF) in patients with periodontitis. There were two groups consisting of individuals who had periodontitis and those who were healthy, with 24 individuals in each group. Periostin levels were assessed at baseline, at the 24th h, 48th h, 14th day 1st month, 3rd month after non-surgical periodontal treatment in serum and GCF samples by the Elisa method in the first study. In parallel, interleukin 1 (IL)-beta and fibroblast growth factor levels were measured. Progranulin levels were assessed at baseline, at the 24th h, 48th h, 14th day 1st month, 3rd month after non-surgical periodontal treatment in serum and GCF samples by the Luminex method in the second study. In parallel, vascular endothelial growth factor, IL-1 beta, tumor necrosis factor-alpha, and IL-10 levels were measured.
Study Details
Timeline
Interventions
Full month non-surgical periodontal treatment procedure was applied to the periodontitis group.