CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 246,295 enrolled
Drug / intervention
Enhanced texts with Callback by a Person +1 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05535777
NCT05535777N/ACompleted

Improving Influenza Vaccination Delivery Across a Health System by the Electronic Health Records Patient Portal RCT 5 (LADHS)

University of California, Los Angeles·interventional·Posted Sep 10, 2022·Updated Apr 11, 2025

In Brief

A clinical study evaluating Enhanced texts with Callback by a Person and Enhanced Bidirectional Texts for Influenza and Respiratory Tract Infections. Completed, enrolled 246,295 participants across 2 sites.

Detailed Summary

This trial is taking place in Los Angeles, CA at clinics within the Los Angeles Department of Health clinics. The study design is a comparative effectiveness trial design. Patients will be randomized into 1) receiving enhanced texting with a callback by a trained call-center staff member to schedule a vaccine visit if the patient presses "1" in response to the text, 2) receiving enhanced bidirectional texting with a texting response from a trained call-center staff member who will help the patient schedule a vaccine visit through a series of back-and-forth texts, or 3) standard text reminders (control group). Patients in all arms will receive reminders if they are due for influenza vaccine. Despite the Advisory Committee on Immunization Practices (ACIP) recommendation in 2010 that all people above 6 months of age should receive an annual flu vaccine, vaccination rates remain low: at 6m-4.9 yrs. (70%), 5-17.9 yrs. (56%), 18-64.9 yrs. (38%), and \>65 yrs. (63%). The investigators will assess the effectiveness of enhanced text R/R messages as compared to the standard of care control (standard text reminders).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

N/ACompletedFinished
2023202420252026
First PostedSep 10, 2022
Enrollment StartSep 13, 2022
Primary CompletionMar 31, 2023
TodayJul 2, 2026
Enrollment to primary: 7 monthsPosted 3.8 years ago

Interventions

Enhanced texts with Callback by a Personbehavioral

Enhanced texts - Callback by a person: Patient randomized to this study arm will receive a phone call back by a call center agent if they press "1" in response to a question on the original text message. The call center agent's job is to schedule patients for clinical visits. These call center agents will be trained by our faculty and staff and will have the usual HIPAA and other patient confidentiality training.

Enhanced Bidirectional Textsbehavioral

Patients randomized to this study arm will receive a text message from a call center agent if they press "1" in response to a question on the original text message. The bidirectional texts will have an agent who can answer questions and schedule an appointment through text message back-and-forth conversations with the patient.