At a glance
ClinicalIndex Comparison Record- ✓Age greater than 18 years
- ✓Histological, cytological, or radiological confirmation of solid tumor malignancy
- ✓Clinical indication for surgical resection of one brain metastasis
- ✓Controlled or responsive extracranial metastatic lesions
- ✕Prior whole brain radiotherapy (WBRT)
- ✕Diagnosis of small cell lung cancer, germinal cell tumor, or lymphoproliferative disease
- ✕Pregnant women
- ✕Prior open neurosurgery for malignancy
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Phase III Randomized Trial Comparing Preoperative Hypofractionated Radiosurgery (HSRS) to Postoperative Hypofractionated Radiosurgery (HSRS) for Patients With Large Brain Metastases (= 2.1cm) Suitable for Surgical Resection
In Brief
A clinical study evaluating Hypofractionated Radiosurgery (HSRS) and Brain metastases surgical resection for Brain Metastases, Adult. Currently recruiting, targeting 146 participants across 9 sites.
Signals
Detailed Summary
This is a phase III randomized trial with the aim to compare preoperative HSRS to postoperative HSRS in patients with large at least one BMs from solid tumors suitable for surgical resection.
Study Details
Timeline
Interventions
HSRS converges multiple radiation beams to deliver a single, large dose of radiation to a discrete tumor target with high precision, thereby minimizing radiation dose to the surrounding normal tissue.
Complete surgical resection of brain lesions with adeguate margins.