CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 36 enrolled
Drug / intervention
High Ultra Processed Food Diet +1 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05550818
NCT05550818N/ACompleted

Influence of Ultra-processed Foods on Reward Processing and Energy Intake

Virginia Polytechnic Institute and State University·interventional·Posted Sep 22, 2022·Updated Jan 12, 2026

In Brief

A clinical study evaluating High Ultra Processed Food Diet and No Ultra Processed Food Diet for Eating Behavior and Eating Habit. Completed, enrolled 36 participants across 2 sites.

Detailed Summary

Most individuals with obesity become so before age 35 and adolescent's unhealthy dietary patterns, specifically high intake of ultra-processed foods and poor overall diet quality, may contribute to energy overconsumption and weight gain. The overall objective of this research is to establish proof-of-concept for altered reward processing measured by brain response to ultra-processed foods, an increase in ad libitum energy intake, and adverse effects on executive function in response to an ultra-processed diet (81% total energy) compared to a diet emphasizing minimally processed foods in individuals aged 18-25 years.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
2023202420252026
First PostedSep 22, 2022
Enrollment StartMar 10, 2023
Primary CompletionDec 15, 2024
Study CompletionJun 10, 2025
TodayJul 2, 2026
Enrollment to primary: 1.8 yearsPosted 3.8 years ago

Interventions

High Ultra Processed Food Dietother

Participants will be provided and consume a diet emphasizing UPF (81% energy). Diets will be eucaloric (50% carbohydrate, 35% fat,15% protein) matched for dietary soluble and insoluble fiber, added sugar, mono- and polyunsaturated fat, saturated fat, antioxidant nutrients, sodium, and overall diet quality, for 2 weeks.

No Ultra Processed Food Dietother

Participants will be provided and consume a diet containing no UPF (0% energy). Diets will be eucaloric (50% carbohydrate, 35% fat,15% protein) matched for dietary soluble and insoluble fiber, added sugar, mono- and polyunsaturated fat, saturated fat, antioxidant nutrients, sodium, and overall diet quality, for 2 weeks.